Primarily, the type 7 strains of JCPyV were detected, among which 45.5% (15/33) were subtype 7A, 30.3% (10/33) were 7B, and 24.2% (8/33) were 7C. Six nucleotide mutations, as well as one amino acid substitution, were isolated from the patients. Conclusions Urine samples from HIV-1-infected patients from Zhejiang Province show a high JCPyV infection rate. The most common JCPyV strains are subtypes 7A, 7B, and 7C. JC polyomavirus (JCPyV) human immunodeficiency virus-1 (HIV-1) prevalence progressive multifocal leukoencephalopathy (PML) subtype urine variant. Padgett BL, Walker DL, ZuRhein GM, et al. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. JC virus load in cerebrospinal fluid and transcriptional control region rearrangements may predict the clinical course of progressive multifocal leukoencephalopathy. DNA rearrangements in organ-specific variants of polyomavirus JC strain GS.
Major EO, Amemiya K, Tornatore CS, et al.
Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Iannetta M, Bellizzi A, Lo Menzo S, et al.
